Alkyl chlorides
Medchemexpress LLC Spi-112 | 1051387-90-6 | MFCD31620831 | 98.0% | 468.46 g/mol | C22H17FN4O5S | 1 ML
SPI-112 is a potent, selective, and competitive inhibitor of SHP2 (PTPN11) used for in vitro biochemical and biophysical studies. It inhibits SHP2 with an IC50 of approximately 1 μM, with weaker activity against related phosphatases. Kinetic and binding data indicate competitive inhibition (Ki ≈ 0.8 μM) and 1:1 binding by SPR (KD ≈ 1.3 μM). The compound is not cell permeable and is supplied for research applications.
- Inhibits SHP2 with IC50 ≈ 1 μM.
- Shows selectivity over related phosphatases (IC50s 18.3 μM for PTP, 14.5 μM for PTP1B).
- Exhibits competitive inhibition kinetics (Ki ≈ 0.8 μM).
- Binds 1:1 in SPR with KD ≈ 1.3 μM.
- Not cell permeable due to polar or charged functional groups.
- Supplied as a solid and as a 10 mM solution for in vitro assays.
- High purity suitable for biochemical assays (≈98%).
- Store solid at 4°C; in solvent store at -80°C (long term) or -20°C (short term).
eMolecules 4-Fluorobiphenyl | 324-74-3 | 5G | Purity: 97%
Matrix Scientific | 4-Fluorobiphenyl | 5G | 324-74-3 | MFCD00011650
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Apexbio Technology LLC I-CBP 112 1640282-31-0 5mg
I-CBP 112 (CAS 1640282-31-0) is a selective small-molecule inhibitor targeting the bromodomains of CREBBP (CBP) and EP300 two epigenetic regulators involved in transcriptional control In biochemical assays I-CBP 112 demonstrates an IC50 of 170 nM against CREBBP with marked selectivity over other bromodomain-containing proteins such as ATAD2 BAZ2B and members of the BET family In vitro studies indicate that I-CBP 112 does not exhibit significant cytotoxicity in U2OS cells at concentrations up to 50 M Currently this compound is utilized predominantly in cellular and molecular studies to dissect the function of CREBBP/EP300 bromodomains in gene regulation with ongoing use limited to preclinical in vitro research contexts
eMolecules Key Organics/BIONET 2 4-dichloro-3-(trifluoromethyl)pyridine 10mg 564136012 HD-0214 97 000 1186194-98-8 MFCD12547046 215 980 C6H2Cl2F3N
Key Organics/BIONET 2 4-dichloro-3-(trifluoromethyl)pyridine 10mg 564136012 HD-0214 97 000 1186194-98-8 MFCD12547046 215 980 C6H2Cl2F3N
Sigma Aldrich Fine Chemicals Biosciences 1 Methylnaphthalene 955KG
1-Methylnaphthalene occurs in Chinese raw spirits brown millet milled millet and millet bran. This volatile organic compound (VOC) is also found in the diesel engine exhaust gas and in the manures of cow hog and chicken.
